Chemo- / Antikörpertherapien bei Darmkrebs

[Jutta]

Cisplatin No Better than Standard Therapy for Anal Canal Cancer

Replacing mitomycin with cisplatin in chemoradiotherapy for cancer of the anal canal failed to improve either disease-free or overall survival and resulted in more patients needing colostomies, according to a study in the April 23 issue of the Journal of the American Medical Association.

Current standard therapy for anal canal cancer consists of fluorouracil plus mitomycin and radiotherapy. Previous studies have established that chemoradiation is more effective for smaller tumors. Researchers wondered whether initial chemotherapy with fluorouracil and cisplatin could improve outcomes by shrinking tumors before they were treated with the same agents and radiotherapy.

Quelle: http://www.cancer.gov/ncicancerbulletin/NCI_Cancer_Bulletin_042908/page3